Hagop M Kantarjian Selected Research

bcr-abl Fusion Proteins

1/2020	Venetoclax and BCR-ABL Tyrosine Kinase Inhibitor Combinations: Outcome in Patients with Philadelphia Chromosome-Positive Advanced Myeloid Leukemias.
1/2020	Long-term follow-up of lower dose dasatinib (50 mg daily) as frontline therapy in newly diagnosed chronic-phase chronic myeloid leukemia.
10/2015	Synergistic effects of p53 activation via MDM2 inhibition in combination with inhibition of Bcl-2 or Bcr-Abl in CD34+ proliferating and quiescent chronic myeloid leukemia blast crisis cells.
1/2011	Nilotinib is effective in patients with chronic myeloid leukemia in chronic phase after imatinib resistance or intolerance: 24-month follow-up results.
9/2009	Triptolide induces cell death independent of cellular responses to imatinib in blast crisis chronic myelogenous leukemia cells including quiescent CD34+ primitive progenitor cells.
5/2008	Molecular monitoring in chronic myeloid leukemia: response to tyrosine kinase inhibitors and prognostic implications.
2/2008	Favorable long-term follow-up results over 6 years for response, survival, and safety with imatinib mesylate therapy in chronic-phase chronic myeloid leukemia after failure of interferon-alpha treatment.
1/2008	Targeted therapy in chronic myeloid leukemia.
11/2007	Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is effective in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intolerance.
11/2005	Targeting the kinase activity of the BCR-ABL fusion protein in patients with chronic myeloid leukemia.

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Hagop M Kantarjian Research Topics

Disease

151	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 11/2022 - 06/2002
136	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/2022 - 03/2002
98	Neoplasms (Cancer) 01/2022 - 07/2002
84	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 09/2022 - 01/2002
79	Philadelphia Chromosome 09/2022 - 04/2002
73	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/2022 - 05/2002
72	Leukemia 01/2022 - 02/2002
31	Primary Myelofibrosis (Myelosclerosis) 10/2020 - 04/2003
26	Hematologic Neoplasms (Hematological Malignancy) 01/2020 - 01/2002
20	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 01/2022 - 04/2003
20	Blast Crisis (Blast Phase) 06/2021 - 05/2002
19	Thrombocytopenia (Thrombopenia) 11/2021 - 09/2002
19	Residual Neoplasm 01/2021 - 01/2003
15	Neutropenia 11/2021 - 06/2003
14	Disease Progression 01/2021 - 03/2002
14	Exanthema (Rash) 01/2021 - 03/2003
14	Diarrhea 01/2019 - 08/2002
12	Infections 10/2021 - 01/2002
12	Myeloid Leukemia (Leukemia, Myelocytic) 01/2020 - 06/2002
12	Anemia 01/2019 - 04/2002
11	Fibrosis (Cirrhosis) 01/2022 - 07/2005
11	Acute Promyelocytic Leukemia 01/2022 - 06/2002
11	Fatigue 01/2021 - 04/2003
11	Splenomegaly 01/2019 - 10/2004
10	Chromosome Aberrations (Chromosome Abnormalities) 01/2018 - 04/2004
9	Lymphoma (Lymphomas) 01/2019 - 12/2003
8	Febrile Neutropenia 11/2021 - 02/2010
8	Polycythemia Vera 01/2017 - 06/2006
7	Cytopenia 01/2021 - 05/2006
7	Pleural Effusion (Pleural Effusions) 01/2020 - 06/2005
7	Chronic Myelomonocytic Leukemia (Leukemia, Chronic Myelomonocytic) 07/2015 - 04/2003
6	Pneumonia (Pneumonitis) 01/2022 - 09/2007
6	Pathologic Complete Response 01/2019 - 06/2002
6	Nausea 01/2018 - 09/2003
5	Hairy Cell Leukemia 01/2022 - 12/2003
5	Edema (Dropsy) 01/2019 - 08/2002
5	Vomiting 01/2019 - 09/2003
5	Fever (Fevers) 01/2018 - 06/2005
5	Essential Thrombocythemia 10/2017 - 06/2006
5	Headache (Headaches) 11/2015 - 04/2003
5	Pain (Aches) 10/2014 - 04/2003

Drug/Important Bio-Agent (IBA)

90	Imatinib Mesylate (Gleevec)FDA Link 07/2021 - 03/2002
68	Tyrosine Kinase InhibitorsIBA 09/2022 - 09/2003
47	Cytarabine (Cytosar-U)FDA LinkGeneric 11/2022 - 04/2002
35	Decitabine FDA Link 12/2021 - 08/2003
33	Dasatinib (BMS 354825)FDA Link 05/2022 - 02/2007
31	Proteins (Proteins, Gene)FDA Link 01/2022 - 06/2002
29	venetoclaxIBA 11/2022 - 12/2015
27	nilotinib FDA Link 07/2021 - 02/2007
25	Pharmaceutical PreparationsIBA 01/2022 - 08/2002
25	Azacitidine (5 Azacytidine)FDA Link 01/2022 - 05/2002
22	ruxolitinibIBA 10/2020 - 01/2009
19	Phosphotransferases (Kinase)IBA 01/2019 - 11/2005
18	Inotuzumab OzogamicinIBA 01/2022 - 08/2016
15	blinatumomabIBA 09/2022 - 03/2014
15	Clofarabine (Clolar)FDA Link 02/2017 - 03/2003
14	Rituximab (Mabthera)FDA Link 01/2022 - 04/2003
13	bosutinibIBA 06/2021 - 05/2011
13	Vincristine (Oncovin)FDA LinkGeneric 01/2021 - 01/2002
13	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2021 - 01/2002
13	bcr-abl Fusion ProteinsIBA 01/2020 - 03/2002
12	fludarabineIBA 01/2022 - 04/2002
12	Idarubicin (4 Demethoxydaunorubicin)FDA LinkGeneric 08/2021 - 06/2002
12	Dexamethasone (Maxidex)FDA LinkGeneric 01/2021 - 01/2002
11	NucleosidesIBA 06/2014 - 02/2002
10	ponatinibIBA 05/2022 - 06/2013
10	Monoclonal AntibodiesIBA 01/2021 - 04/2003
10	DNA (Deoxyribonucleic Acid)IBA 01/2019 - 06/2002
9	Interferon-alpha (Interferon Alfa)IBA 02/2008 - 04/2002
8	Reticulin (Reticular Fiber)IBA 01/2022 - 07/2005
8	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2021 - 01/2002
8	Lenalidomide (CC 5013)FDA Link 01/2021 - 08/2006
8	CytokinesIBA 01/2020 - 07/2003
7	Gemtuzumab (Mylotarg)FDA Link 01/2022 - 06/2002
7	enasidenibIBA 01/2022 - 10/2017
7	Methotrexate (Mexate)FDA LinkGeneric 01/2018 - 04/2003
6	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2022 - 06/2002
6	Arsenic Trioxide (Trisenox)FDA Link 01/2022 - 09/2004
6	Core Binding Factors (Core-Binding Factor)IBA 01/2022 - 05/2009
6	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 10/2021 - 01/2002
6	MethyltransferasesIBA 01/2021 - 08/2007
6	Transaminases (Aminotransferases)IBA 01/2020 - 01/2008
6	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2020 - 05/2002
6	Janus Kinase 2IBA 01/2019 - 11/2005
6	Hemoglobins (Hemoglobin)IBA 02/2014 - 04/2002
6	Janus Kinase InhibitorsIBA 02/2014 - 01/2013
6	Biological ProductsIBA 03/2013 - 07/2002
6	troxacitabineIBA 01/2007 - 02/2002
5	fms-Like Tyrosine Kinase 3IBA 01/2022 - 10/2012
5	NucleophosminIBA 01/2021 - 10/2009
5	Histone Deacetylase InhibitorsIBA 12/2017 - 11/2006
5	InterferonsIBA 01/2017 - 06/2003
5	HomoharringtonineIBA 01/2016 - 04/2002

Therapy/Procedure

208	Therapeutics 09/2022 - 04/2002
57	Drug Therapy (Chemotherapy) 01/2022 - 01/2002
14	Salvage Therapy 01/2021 - 10/2008
12	Stem Cell Transplantation 12/2019 - 09/2002
10	Induction Chemotherapy 01/2022 - 01/2002
9	Drug Tapering 01/2020 - 06/2003
7	Aftercare (After-Treatment) 06/2021 - 08/2002